Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered modified nucleosides: ct6A, ms2ct6A, ges2U.

Opus 13 2018-2020

Biosynthesis of seleno-modified nucleosides in the anticodon loop of transfer ribonucleic acids. Evaluation of the enzymatic transformation of 2-thiouridine to 2-selenouridine, studies on function and structure of E. coli tRNA selenouridine synthase.

Opus 7 2015-2018

Studies on a new method for the synthesis of oligoribonucleotides modified with 5-aminomethyluridines (xnm5U) and 5-aminomethyl-2-thiouridines (xnm5s2U) via post-synthetic nucleophilic substitution of 5-pivaloyloxymethyluridine/2-thiouridine.

Preludium 9 2016-2017

Studies on the synthesis of newly discovered cyclic N6-threonylcarbamoyladenosine (ct6A) and its analogues and on the introduction of ct6A into oligoribonucleotide chain.

Preludium 7 2015-2016