Elżbieta Sochacka's Research Group

 

          

 

Contact


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ORCID: https://orcid.org/0000-0001-8094-6741

 

Publications


 

Synthesis of Nucleobase-Modified RNA Oligonucleotides by Post-Synthetic Approach.

 

Bartosik, K., Debiec, K., Czarnecka, A., Sochacka, E., Leszczynska, G. Molecules 202025(15), 3344

 

 

Post-synthetic conversion of 5-pivaloyloxymethyluridine present in a support-bound RNA oligomer into biologically relevant derivatives of 5-methyluridine.

Bartosik, K., Sochacka, E., Leszczynska, G. Org. Biomol. Chem. 201715(9), 2097-2103.

 

Synthesis of various substituted 5-methyluridines (xm5U) and 2-thiouridines (xm5s2U) via nucleophilic substitution of 5-pivaloyloxymethyluridine/2-thiouridine.

Bartosik, K., Leszczynska, G.,Tetrahedron Lett.201556, 6593-6597.

 

Chemical synthesis of the 5-taurinomethyl(-2-thio)uridine modified anticodon arm of the human mitochondrial tRNALeu(UUR) and tRNALys.

Leszczyńska, G., Leonczak P., Wozniak, K., Malkiewicz, A. RNA 2014,20, 938-947.

 

Site-selected incorporation of 5-carboxymethylaminomethyl(-2-thio)uridine into RNA sequences by phosphoramidite chemistry.

Leszczynska, G., Pięta, J., Wozniak, K., Malkiewicz, A. Org. Biomol. Chem. 201412, 1052-1056. 

 

Chemical synthesis of human mitochondrial tRNAlys fragment containing 5-taurinomethyl-2-thiouridine and 6-threonylcarbamoyladenosine.

Wozniak, K., Stasiak, A., Leonczak, P., Leszczynska, G., Malkiewicz, A., Coll. Czech. Chem. Commun., Symp. Series, 201414, 408-410.