CHEMISTRY OF MODIFIED AND HYPERMODIFIED NUCLEOSIDES

• New strategies for the synthesis of natural components of ribonucleic acids (mainly tRNA and mt-tRNA) and their analogues; full characteristics of their properties
• Structural studies of modified nucleosides
• Study on the transformation of modified nucleosides under conditions that mimic oxidative stress in the cell.

MODIFIED RNA AND DNA FRAGMENTS

• Synthesis of modified monomeric units suitable for solid phase phosphoramidite synthesis
• Optimization of the synthesis protocols of modified RNA / DNA fragments
• Research on the introduction of modified nucleosides into the RNA / DNA chain by post-synthetic transformations of precursor oligomers.